This study was done March 2018. For a long time now, it has been suspected that aluminum has played a role in the Autism Spectrum Disorder (ASD) condition and especially the high and swift rise in cases. In 1995 it was approximately 1 in 500, 2005 it was approximately 1 in 165, in 2015 it was approximately 1 in 50. In compare with other disabilities there is none even close.
In this study MatthewMoldDorcasUmarAndrewKingChristopherExley applied and were granted leave to dissect and analyze brain tissue of 5 donor brains having belonged to 5 people, 4 male and 1 female, that were diagnosed in life with having ASD. They used fluorescence microscopy to observe and chart their data. Their findings were recorded and, though is was a small study, it has garnered a fair amount of attention. The analysis revealed startling levels of aluminum in these brains, but especially high in the male brains. In a normal healthy human brain aluminum should be no higher than 2 μg/g. of tissue, but on average most studied brain tissue has had numbers under 1 μg/g. All 5 of these specimens were over this average level.
Different areas of the brains had higher levels than others but the most effected area for most seemed to be the occipital region, though various ones had peaks throughout the five.
Table 1. Aluminium content of occipital (O), frontal (F), temporal (T) and parietal (P) lobesand hippocampus (H) of brain tissue from 5 donors with a diagnosis of autism spectrum disorder.
|Donor ID||Gender||Age||Lobe||Replicate||[Al] μg/g|
|Mean (SD)||1.69 (2.22)|
|Mean (SD)||1.01 (0.08)|
|Mean (SD)||1.14 (0.02)|
|Mean (SD)||0.86 (0.45)|
|All||Mean (SD)||1.20 (1.06)|
|Mean (SD)||5.03 (2.46)|
|Mean (SD)||1.13 (0.45)|
|Mean (SD)||1.69 (0.92)|
|Mean (SD)||6.41 (10.54)|
|All||Mean (SD)||3.40 (5.00)|
|Mean (SD)||1.10 (0.79)|
|Mean (SD)||2.86 (1.22)|
|Mean (SD)||2.81 (1.33)|
|Mean (SD)||2.82 (1.81)|
|All||Mean (SD)||2.40 (1.58)|
|Mean (SD)||8.74 (11.59)|
|Mean (SD)||2.00 (1.10)|
|Mean (SD)||1.49 (0.37)|
|Mean (SD)||4.05 (3.77)|
|All||Mean (SD)||3.73 (6.02)|
|Mean (SD)||2.54 (0.74)|
|Mean (SD)||5.62 (3.75)|
|Mean (SD)||6.82 (8.91)|
|Mean (SD)||4.21 (1.87)|
|All||Mean (SD)||4.77 (4.79)|
As you can see from the above graph, the average from all 5 was 4.77μg/g. That is twice what the highest in normal should be. These specimens came from 5 different age groups. The oldest being a 50-year-old male and the youngest being a 15 year male. The fact that they found such high amounts in the youngest donor’s sample was especially alarming, but not surprising, as this individual would have likely have received the most vaccinations of the group because of the birth year and vaccine schedule changes that had happened. Now, the interpretations of this study are not settled nor are they unequivocal. The youngest, though, wasn’t the highest overall, but was the highest in the occipital region.
The high amounts in the older specimens could have been caused by years of accumulation from environmental sources. It wouldn’t explain why aluminum happened to be found in these types of brains in such high amounts, though.
Theories on why some people may have the tendency to have aluminum more readily invade and remain in the brains of some but not others could have to do with mitochondrial issues and MTHFR gene mutations. People with 2 types of MTHFR gene mutations have been noted to be linked with neurological issues. There is a theory that people with certain types of MTHFR mutations may have more sensitivity to metals and possible inability to detoxify from them fully. A lot of this is still theory with few studies being done on connections, but there are a few studies showing at least modest connections to this theory. The three linked above are interesting reads for sure. MTHFR is definitely linked with inflammation though, especially it seems cardiovascular.
So, there is still so much more research that needs to be done to follow-up this autism and aluminum link. Why and how are they related? Are the aluminum adjuvants in vaccines worsening this underlying possible condition due to MTHFR or mitochondrial issues and triggering neurological problems? These are sound theories. They need to be followed up on to help people make decisions to better help with the health of them self and their children.
To read the full Brain in Aluminum study, it can be found here .
The several MTHFR studies have been linked several places above.
A study linking metals and other neurodegenerative conditions can also be found here.
If you have any further info to add or better studies to more broaden this subject feel free to contact us.